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Learning Objectives Understand how incretin signaling (GLP-1 and GIP) integrates with insulin and glucagon across organs to regulate glucose homeostasis, appetite, and energy balance

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial

Despite the limitations like small sample size, the recruitment limited to two stages of DKD, the assessment of only an acute effect of the drug our study found a short-term hypertensive effect of GLP-1R agonist liraglutide in diabetic kidney disease that seems to be related to impaired renal sodium excretion

Author contributions WZ, JC, and HX designed and wrote the paper

Always check with a doctor if chills come with symptoms like fever, sickness, or feeling very weak